Chapter 157 The Development Of Antibiotics Depends On Digging?
Chapter 157 The Development Of Antibiotics Depends On Digging?
Jinghai University, the gate of the school.
At sunset, a group of high school students stood in front of the bus stop and said goodbye to a handsome boy.
"Since you are not going back to school, I will continue to use your meal card next week!" Zhao Yiyi was happy.
"Use it, use it, little idiot." Song He was helpless.
"I just made a fortune, you will have a big happy event next week!" Yuan Guang said seriously.
"Really? I'll give you a good word!" Song He's eyes lit up. The half-immortal dormmate is said to be a descendant of Yuan Tiangang, with awakened blood and excellent divination skills, so he is trustworthy.
"When you come back next week, we will go to the toilet to study together at night!" Ding Yangze and Ning Mo said, "It's better for us to kick the wall and turn on the lights. Chu Long and Leng Xiangwen have no sense of rhythm."
Song He laughed loudly, "Okay! Let's form a toilet band later!"
"Let's compete for the next math test." Chu Long stroked his bald head with serious eyes.
"No way, Brother Long! You've reached the full boss level, and I'm still fighting the five scumbags." Song He said modestly.
Leng Xiangwen's face twitched, you are the five scum of the war, what am I?
"Come on! Eat well!" Zhuang Qiyan cared, "Don't study too hard, your body is the most important thing!"
"Don't worry! I'm as powerful as a dragon!" Song He is confident.
The bus was coming slowly, and the students finally waved to Song He and got on the bus.
Standing on the side of the road, watching the bus go away, Song He turned back to school.
Hanging out with friends for a day is very relaxing and comfortable, and there is a sense of happiness.
However, heroes should not be drunk to death, a new battle is about to start!
Song He trotted all the way and hurried back to the laboratory.
It happened to be meal time, and the students all left the laboratory to cook.
However, the three professors are still busy in the first laboratory, working hard, like tireless scientific research machines!
Song He admired him, he is young now and can work tirelessly. The three professors are all middle-aged and elderly, but they can still work so hard! Could this be the real veteran powerhouse?
"Old Lu! Your little apprentice is here!" Tao Miaochun glanced at Song He and smiled.
Lu Chengen glanced back quickly, still busy operating the instrument, "Xiao Song, come in and sit down!"
Lu Chengen called "Xiao Song" very kindly, and Ji Zining next to him couldn't help but look up. As an old colleague, he had never seen old Lu call a student like that.
Ji Zining thought about it for a while, and he could fully understand that if he had such an outstanding student, he would not call him Xiao Song, but Xiao Baobao!
"Teacher, I want to learn how to make antibiotics!" Song He pulled the chair over and sat down next to Lu Chengen.
"Learn to make antibiotics?" Lu Chengen was surprised, "You are still too young... um... you can try it!"
Song He was immediately delighted, he was able to go to the first laboratory to learn how to make antibiotics, this trip was not in vain!
"Wait until I'm done with this set of sequencing, and I'll tell you about antibiotics!" Lu Chengen kept moving his hands, "Go to Professor Ji first and learn about flow cytometry."
Song He nodded obediently, and ran to Ji Zining's side.
Ji Zining resolutely started poaching, "Song He, look at the bad master you're looking for, but he didn't take you personally! Send you over to find me, old Lu Mingming just doesn't value you!"
"Lao Lu doesn't value you, but I value you! Why don't you join me instead, and I'll teach you to be a biologist..."
Lu Chengen's face darkened, "I'm almost done, Xiao Song, come back!"
Song He couldn't laugh or cry, a group of old professors with white hair and snow, how could they behave like children?
A minute later, Lu Chengen stopped what he was doing, sat down, and faced Song He seriously.
As a senior old professor, there are as many students who study with him as crucian carp crossing the river, and it has been many years since he taught a small lesson to a student alone.
"I don't know how much you know about antibiotics. If you have any questions, feel free to ask!" Lu Chengen smiled.
"Teacher, I want to know how to develop the current antibiotics?" Song He asked, "It is to learn some knowledge about antibiotics. After learning to a certain extent, do you know how to make new antibiotics?"
Lu Chengen shook his head and said with a smile, "Knowledge is of course useful, but knowledge can only help you do one thing, guess!"
"Guess?" Song He was thoughtful.
"Guess, try, these are the two methods that humans currently use to create antibiotics." Lu Chengen said, "Although we have developed a bunch of expensive and advanced instruments, the process of developing new antibiotics is still very primitive."
"How primitive?" Song He was stunned.
"Professor Ji worked for Wyeth Pharmaceuticals when he was young, and his job at that time was digging soil." Professor Lu said.
"It took me a whole year to dig the soil!" Ji Zining sighed, and the old man always likes to recall, "At that time, I bought a second-hand Volkswagen van, which was equipped with a sink gas lamp and some sampling tools. My girlfriend drove in front. , I looked around from behind, shouting to stop from time to time!"
"After parking the car, I will rush down and dig a bag of soil. If I drive by the coast, I will dig a bag of white sand up."
"After digging up the soil and sand, I was busy diluting the samples and making petri dishes. I will take them to the laboratory the next day to see if there are any suitable bacteria."
Song He was dumbfounded, "Just dig the soil randomly, and find suitable bacteria from the soil to make antibiotics?"
"That's right!"
After Ji Zining finished speaking, he was very satisfied when he saw Song He's stunned expression, so he paused and continued.
"Some of my colleagues come from pharmaceutical giants such as Pfizer, Novartis, Merck, etc., and they do the same work as me, except that I pray to Buddha before digging, and they make the sign of the cross before digging."
"Pharmaceutical giants spend billions of dollars to build biological laboratories, but the so-called scientific demonstration and careful planning are useless, or even non-existent! Antibiotic research and development has always been this way, dig some soil and bring it back to the laboratory for analysis."
"I've been digging and digging, our colleagues are disheartened every day, and they don't look good in the marriage and love market." Ji Zining joked.
"At that time, Lao Ji found a foreign girl girlfriend, who was a local rich woman. He didn't have to work hard, but Lao Ji was obsessed with digging the soil every day, and his little girlfriend felt left out, so they broke up tearfully." Tao Miaochun giggled beside her. laugh.
Ji Zining looked calm, "My old Ji is also from a famous family, how can the ancestral chromosomes be handed over to Fan people? I dug the soil for more than 200 days that year, and successfully produced a veterinary antibiotic for the benefit of mankind. What kind of?"
Song He almost wanted to applaud, Professor Ji is the legendary Sigma man?
"Come back to business." Lu Chengen stopped the gossip discussion, "You also heard that the main method of antibiotic research and development is trial and error!"
"For example, streptomycin was found by Waxman with more than 50 students and screened more than 10,000 soil strains. Pingyangmycin was found by Song Ailan from the soil of Pingyang County. Chloramphenicol was found in the soil of Venezuela. Found it. Erythromycin was isolated from a soil sample in the Philippines."
"The famous antibiotics in history basically relied on excavating soil, a lot of trial and error screening, and finally came out by chance."
"One side of water and soil produces one side of antibiotics, do you understand?" Lu Chengen smiled, "Do you know the principle behind it?"
"There are many bacteria and fungi in the soil, and the ecological niches are similar. Antibiotics are chemical weapons used by fungi to fight against each other?" Song He guessed, "One kind of bacteria secretes antibiotics, poisons other bacteria alive, and can occupy the living space?"
"Smart!" Lu Chengen praised.
"Can I just dig the soil and try my luck? There is no antibiotic that can be produced in the laboratory by using knowledge?" Song He's face turned bitter.
"Yes!" Lu Chengen said immediately.
allendalepharm